| 2. Round | 08/08/2007 | FC Schalke 04 II | - | Delbrücker SC | 1:2 | ||||
| 8. Round | 16/09/2007 | Arminia Bielefeld II | - | FC Schalke 04 II | 1:2 | ||||
| 11. Round | 03/10/2007 | FC Schalke 04 II | - | Hammer SpVg | 3:1 | ||||
| 12. Round | 07/10/2007 | SpVgg Erkenschwick | - | FC Schalke 04 II | 2:1 | ||||
| 13. Round | 21/10/2007 | FC Schalke 04 II | - | FC Gütersloh 2000 | 0:0 | ||||
| 21. Round | 24/02/2008 | SC Wiedenbrück | - | FC Schalke 04 II | 0:5 | ||||
| 22. Round | 02/03/2008 | FC Schalke 04 II | - | FCE Rheine | 2:0 | ||||
| 26. Round | 30/03/2008 | Westfalia Herne | - | FC Schalke 04 II | 3:1 | ||||
| 29. Round | 20/04/2008 | FC Schalke 04 II | - | SpVgg Erkenschwick | 2:1 | ||||
| 30. Round | 27/04/2008 | FC Gütersloh 2000 | - | FC Schalke 04 II | 0:1 | ||||
| 31. Round | 04/05/2008 | FC Schalke 04 II | - | SV Schermbeck 1912 | 1:1 | ||||
| 32. Round | 18/05/2008 | Germania Gladbeck | - | FC Schalke 04 II | 1:1 | ||||
| 33. Round | 25/05/2008 | FC Schalke 04 II | - | SF Oestrich-Iserlohn | 1:1 | ||||
| 34. Round | 01/06/2008 | TSG Sprockhövel | - | FC Schalke 04 II | 1:2 |
Germany