| 19. Round | 31/01/2021 | 1. FC Heidenheim 1846 | - | FC St. Pauli | 3:4 |  |
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| 21. Round | 13/02/2021 | 1. FC Heidenheim 1846 | - | Erzgebirge Aue | 2:0 | |
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| 22. Round | 20/02/2021 | VfL Osnabrück | - | 1. FC Heidenheim 1846 | 1:2 | |
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| 20. Round | 23/02/2021 | SC Paderborn 07 | - | 1. FC Heidenheim 1846 | 2:2 | |
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| 23. Round | 28/02/2021 | 1. FC Heidenheim 1846 | - | Fortuna Düsseldorf | 3:2 | |
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| 26. Round | 20/03/2021 | Hamburger SV | - | 1. FC Heidenheim 1846 | 2:0 | |
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| 27. Round | 03/04/2021 | 1. FC Heidenheim 1846 | - | SpVgg Greuther Fürth | 0:1 | ||||
| 25. Round | 06/04/2021 | 1. FC Heidenheim 1846 | - | Holstein Kiel | 1:0 | |
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| 28. Round | 11/04/2021 | Hannover 96 | - | 1. FC Heidenheim 1846 | 1:3 | ||||
| 29. Round | 18/04/2021 | Jahn Regensburg | - | 1. FC Heidenheim 1846 | 0:3 | |
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| 30. Round | 21/04/2021 | 1. FC Heidenheim 1846 | - | VfL Bochum | 0:2 | ||||
| 31. Round | 24/04/2021 | 1. FC Nürnberg | - | 1. FC Heidenheim 1846 | 3:1 | |
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| 32. Round | 09/05/2021 | 1. FC Heidenheim 1846 | - | SV Sandhausen | 2:1 | |
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| 33. Round | 16/05/2021 | SV Darmstadt 98 | - | 1. FC Heidenheim 1846 | 5:1 | |
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| 34. Round | 23/05/2021 | 1. FC Heidenheim 1846 | - | Karlsruher SC | 1:2 |
Germany