| 23. Round | 10/04/2022 | MSV 1919 Neuruppin | - | FC Mecklenburg Schwerin | 3:2 | ||||
| 18. Round | 13/04/2022 | Rostocker FC | - | FC Mecklenburg Schwerin | 5:0 | ||||
| 24. Round | 16/04/2022 | FC Mecklenburg Schwerin | - | SFC Stern 1900 | 0:2 | ||||
| 20. Round | 18/04/2022 | FC Mecklenburg Schwerin | - | 1. FC Lok Stendal | 3:1 | ||||
| 25. Round | 24/04/2022 | Eintracht Mahlsdorf | - | FC Mecklenburg Schwerin | 0:1 |  |
 |
||
| 26. Round | 30/04/2022 | FC Mecklenburg Schwerin | - | RSV Eintracht 1949 | 2:2 | |
|||
| 27. Round | 07/05/2022 | Ludwigsfelder FC | - | FC Mecklenburg Schwerin | 2:0 | ||||
| 28. Round | 15/05/2022 | FC Mecklenburg Schwerin | - | Victoria Seelow | 3:0 |
Germany