| 6. Round | 12/09/2021 | 1. FC Heidenheim 1846 | - | Dynamo Dresden | 2:1 | ||||
| 9. Round | 01/10/2021 | Werder Bremen | - | 1. FC Heidenheim 1846 | 3:0 | ||||
| 16. Round | 05/12/2021 | 1. FC Heidenheim 1846 | - | Jahn Regensburg | 3:0 | ||||
| 18. Round | 18/12/2021 | SC Paderborn 07 | - | 1. FC Heidenheim 1846 | 1:2 | ||||
| 19. Round | 16/01/2022 | 1. FC Heidenheim 1846 | - | FC Ingolstadt 04 | 2:1 | ||||
| 21. Round | 04/02/2022 | 1. FC Heidenheim 1846 | - | Hannover 96 | 3:1 | ||||
| 25. Round | 04/03/2022 | SV Darmstadt 98 | - | 1. FC Heidenheim 1846 | 3:2 | ||||
| 26. Round | 12/03/2022 | 1. FC Heidenheim 1846 | - | Werder Bremen | 2:1 | ||||
| 27. Round | 18/03/2022 | FC St. Pauli | - | 1. FC Heidenheim 1846 | 1:0 | ||||
| 28. Round | 03/04/2022 | 1. FC Heidenheim 1846 | - | 1. FC Nürnberg | 3:1 | ||||
| 29. Round | 09/04/2022 | FC Schalke 04 | - | 1. FC Heidenheim 1846 | 3:0 | ||||
| 30. Round | 17/04/2022 | 1. FC Heidenheim 1846 | - | Erzgebirge Aue | 0:2 | ||||
| 31. Round | 23/04/2022 | Holstein Kiel | - | 1. FC Heidenheim 1846 | 1:1 | ||||
| 33. Round | 07/05/2022 | Jahn Regensburg | - | 1. FC Heidenheim 1846 | 0:2 | ||||
| 34. Round | 15/05/2022 | 1. FC Heidenheim 1846 | - | Karlsruher SC | 2:0 |
Germany