| 20. Round | 22/01/2022 | Hansa Rostock | - | 1. FC Heidenheim 1846 | 0:0 | ||||
| 21. Round | 06/02/2022 | Dynamo Dresden | - | Hansa Rostock | 1:4 | ||||
| 22. Round | 11/02/2022 | Hansa Rostock | - | Werder Bremen | 1:2 | ||||
| 23. Round | 20/02/2022 | SV Darmstadt 98 | - | Hansa Rostock | 1:1 | ||||
| 24. Round | 26/02/2022 | Hansa Rostock | - | 1. FC Nürnberg | 0:2 | ||||
| 25. Round | 05/03/2022 | FC Schalke 04 | - | Hansa Rostock | 3:4 | ||||
| 26. Round | 11/03/2022 | Hansa Rostock | - | Holstein Kiel | 3:2 | ||||
| 27. Round | 19/03/2022 | SV Sandhausen | - | Hansa Rostock | 0:1 | ||||
| 28. Round | 02/04/2022 | Hansa Rostock | - | FC St. Pauli | 1:0 | ||||
| 29. Round | 08/04/2022 | Fortuna Düsseldorf | - | Hansa Rostock | 3:0 | ||||
| 30. Round | 17/04/2022 | Hansa Rostock | - | Jahn Regensburg | 1:1 | ||||
| 31. Round | 24/04/2022 | Erzgebirge Aue | - | Hansa Rostock | 2:2 | ||||
| 32. Round | 30/04/2022 | Hansa Rostock | - | SC Paderborn 07 | 0:0 | ||||
| 33. Round | 07/05/2022 | FC Ingolstadt 04 | - | Hansa Rostock | 0:0 |
Germany