| 1. Round | 28/08/2021 | SpVgg Vreden | - | FC Gütersloh | 0:2 | ||||
| 2. Round | 05/09/2021 | TuS Haltern | - | SpVgg Vreden | 1:1 | ||||
| 3. Round | 12/09/2021 | SpVgg Vreden | - | TuS Erndtebrück | 1:1 | ||||
| 6. Round | 03/10/2021 | RSV Meinerzhagen | - | SpVgg Vreden | 0:1 | ||||
| 7. Round | 10/10/2021 | SpVgg Vreden | - | Westfalia Herne | 3:2 | ||||
| 9. Round | 24/10/2021 | SpVgg Vreden | - | Holzwickeder SC | 1:0 | ||||
| 10. Round | 31/10/2021 | ASC 09 Dortmund | - | SpVgg Vreden | 4:2 | ||||
| 11. Round | 07/11/2021 | SpVgg Vreden | - | SG Finnentrop/Bamenohl | 1:1 | ||||
| 13. Round | 20/11/2021 | SpVgg Vreden | - | Viktoria Clarholz | 2:0 | ||||
| 16. Round | 10/12/2021 | SG Wattenscheid 09 | - | SpVgg Vreden | 1:1 | ||||
| 19. Round | 13/03/2022 | SpVgg Vreden | - | Hammer SpVg | 1:0 |
Germany