| 1. Round | 04/08/2012 | SC Verl | - | Sportfreunde Lotte | 2:2 | ||||
| 2. Round | 08/08/2012 | Sportfreunde Lotte | - | 1. FC Köln II | 2:0 | ||||
| 3. Round | 11/08/2012 | Fortuna Köln | - | Sportfreunde Lotte | 3:1 | ||||
| 4. Round | 17/08/2012 | Sportfreunde Lotte | - | Fortuna Düsseldorf II | 1:0 | ||||
| 5. Round | 25/08/2012 | SV Bergisch Gladbach 09 | - | Sportfreunde Lotte | 1:2 | ||||
| 6. Round | 01/09/2012 | Sportfreunde Lotte | - | VfB Hüls | 2:0 | ||||
| 9. Round | 08/09/2012 | FC Schalke 04 II | - | Sportfreunde Lotte | 1:1 | ||||
| 28. Round | 16/03/2013 | Sportfreunde Lotte | - | FC Schalke 04 II | 4:0 | ||||
| 23. Round | 23/03/2013 | Fortuna Düsseldorf II | - | Sportfreunde Lotte | 1:1 | ||||
| 29. Round | 30/03/2013 | SC Wiedenbrück | - | Sportfreunde Lotte | 1:2 | ||||
| 30. Round | 06/04/2013 | Sportfreunde Lotte | - | Viktoria Köln | 0:0 | ||||
| 31. Round | 13/04/2013 | MSV Duisburg II | - | Sportfreunde Lotte | 0:2 | ||||
| 32. Round | 20/04/2013 | Sportfreunde Lotte | - | Bor. Mönchengladbach II | 1:0 | ||||
| 33. Round | 27/04/2013 | VfL Bochum II | - | Sportfreunde Lotte | 1:1 |  |
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| 34. Round | 03/05/2013 | Sportfreunde Lotte | - | Wuppertaler SV | 2:1 | ||||
| 35. Round | 08/05/2013 | Rot-Weiß Oberhausen | - | Sportfreunde Lotte | 1:0 |
Germany