| 1. Round | 22/08/2021 | Cronenberger SC | - | SpVgg Sterkrade-Nord | 2:0 | ||||
| 2. Round | 29/08/2021 | Schwarz-Weiß Essen | - | Cronenberger SC | 2:1 | ||||
| 3. Round | 05/09/2021 | Cronenberger SC | - | FC Kray | 2:2 | ||||
| 4. Round | 12/09/2021 | DJK Teutonia St. Tönis | - | Cronenberger SC | 0:0 | ||||
| 5. Round | 19/09/2021 | Cronenberger SC | - | TuRU Düsseldorf | 0:3 | ||||
| 7. Round | 03/10/2021 | Cronenberger SC | - | 1. FC Monheim | 0:6 | ||||
| 11. Round | 31/10/2021 | Cronenberger SC | - | SC Velbert | 1:1 | ||||
| 12. Round | 07/11/2021 | Sportfreunde Niederwenigern | - | Cronenberger SC | 1:1 | ||||
| 13. Round | 14/11/2021 | Cronenberger SC | - | TV Jahn Hiesfeld | 2:0 |  |
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| 14. Round | 28/11/2021 | SpVg Schonnebeck | - | Cronenberger SC | 3:1 | ||||
| 16. Round | 11/12/2021 | Cronenberger SC | - | SC Union Nettetal | 2:1 | ||||
| 18. Round | 20/02/2022 | Cronenberger SC | - | Sportfreunde Baumberg | 1:3 | ||||
| 19. Round | 25/02/2022 | 1. FC Kleve | - | Cronenberger SC | 3:1 | ||||
| 20. Round | 06/03/2022 | Cronenberger SC | - | TSV Meerbusch | 4:1 | |
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| 22. Round | 20/03/2022 | Cronenberger SC | - | SSVg Velbert | 0:4 |
Germany