| 13. Round | 05/02/2022 | 1. FSV Mainz 05 [Youth] | - | FC Augsburg [Youth] | 5:3 | ||||
| 14. Round | 13/02/2022 | 1. FC Saarbrücken [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:2 |  |
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| 15. Round | 20/02/2022 | 1. FSV Mainz 05 [Youth] | - | VfB Stuttgart [Youth] | 0:3 | |
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| 16. Round | 26/02/2022 | Eintracht Frankfurt [Youth] | - | 1. FSV Mainz 05 [Youth] | 2:2 | ||||
| 17. Round | 05/03/2022 | 1. FSV Mainz 05 [Youth] | - | 1899 Hoffenheim [Youth] | 3:2 |  |
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| 19. Round | 09/04/2022 | 1. FSV Mainz 05 [Youth] | - | 1. FC Nürnberg [Youth] | 3:5 | ||||
| 18. Round | 13/04/2022 | Hessen Kassel [Youth] | - | 1. FSV Mainz 05 [Youth] | 1:6 | |
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| 20. Round | 23/04/2022 | SpVgg Greuther Fürth [Youth] | - | 1. FSV Mainz 05 [Youth] | 1:1 |
Luxembourg
Italy