| 1. Round | 15/08/2021 | VfL Alfter | - | Spvg Wesseling-Urfeld | 3:1 | ||||
| 2. Round | 19/08/2021 | SV Breinig | - | VfL Alfter | 1:2 | ||||
| 3. Round | 22/08/2021 | VfL Alfter | - | BC Viktoria Glesch-Paffendorf | 1:2 | ||||
| 4. Round | 29/08/2021 | FC Pesch 1956 | - | VfL Alfter | 1:1 | ||||
| 5. Round | 05/09/2021 | VfL 08 Vichttal | - | VfL Alfter | 1:4 |  |
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| 6. Round | 12/09/2021 | VfL Alfter | - | SV Deutz 05 | 0:0 | ||||
| 7. Round | 19/09/2021 | 1. FC Düren | - | VfL Alfter | 5:0 | ||||
| 8. Round | 26/09/2021 | VfL Alfter | - | Fortuna Köln II | 2:0 | ||||
| 9. Round | 06/10/2021 | FC Hennef 05 | - | VfL Alfter | 4:1 | ||||
| 10. Round | 10/10/2021 | VfL Alfter | - | FC Hürth | 3:2 | ||||
| 11. Round | 17/10/2021 | SpVg Frechen 20 | - | VfL Alfter | 0:0 | ||||
| 13. Round | 31/10/2021 | Blau-Weiß Friesdorf | - | VfL Alfter | 4:2 | ||||
| 14. Round | 07/11/2021 | VfL Alfter | - | SV Bergisch Gladbach 09 | 0:5 | ||||
| 15. Round | 14/11/2021 | SV 1914 Eilendorf | - | VfL Alfter | 2:0 | |
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| 16. Round | 28/11/2021 | VfL Alfter | - | Viktoria Arnoldsweiler | 2:1 | ||||
| 17. Round | 05/12/2021 | Siegburger SV 04 | - | VfL Alfter | 2:0 | ||||
| 27. Round | 24/04/2022 | FC Hürth | - | VfL Alfter | 1:3 | ||||
| 30. Round | 15/05/2022 | VfL Alfter | - | Blau-Weiß Friesdorf | 1:2 |
Germany