| 1. Round | 22/08/2021 | FSV Duisburg | - | 1. FC Monheim | 2:0 | ||||
| 2. Round | 29/08/2021 | 1. FC Monheim | - | VfB 03 Hilden | 2:1 |  |
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| 4. Round | 12/09/2021 | 1. FC Monheim | - | Sportfreunde Niederwenigern | 0:1 | ||||
| 5. Round | 19/09/2021 | TV Jahn Hiesfeld | - | 1. FC Monheim | 0:2 | ||||
| 6. Round | 26/09/2021 | 1. FC Monheim | - | SpVg Schonnebeck | 1:1 | ||||
| 7. Round | 03/10/2021 | Cronenberger SC | - | 1. FC Monheim | 0:6 |  |
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| 9. Round | 17/10/2021 | SC Düsseldorf-West | - | 1. FC Monheim | 1:4 | ||||
| 10. Round | 23/10/2021 | 1. FC Monheim | - | Sportfreunde Baumberg | 3:0 | ||||
| 11. Round | 31/10/2021 | 1. FC Kleve | - | 1. FC Monheim | 0:1 | |
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| 12. Round | 07/11/2021 | 1. FC Monheim | - | TSV Meerbusch | 1:3 |  |
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| 17. Round | 13/02/2022 | Schwarz-Weiß Essen | - | 1. FC Monheim | 1:0 | |
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| 18. Round | 20/02/2022 | 1. FC Monheim | - | FC Kray | 3:0 | |
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| 19. Round | 27/02/2022 | DJK Teutonia St. Tönis | - | 1. FC Monheim | 0:2 | ||||
| 20. Round | 06/03/2022 | 1. FC Monheim | - | TuRU Düsseldorf | 0:2 | ||||
| 21. Round | 23/03/2022 | Germania Ratingen 04/19 | - | 1. FC Monheim | 1:0 | ||||
| 23. Round | 27/03/2022 | 1. FC Monheim | - | 1. FC Mönchengladbach | 2:0 |
Germany