| 1. Round | 14/08/2021 | SC Spelle-Venhaus | - | VfL Oldenburg | 1:2 | ||||
| 3. Round | 28/08/2021 | Kickers Emden | - | SC Spelle-Venhaus | 1:1 | ||||
| 4. Round | 05/09/2021 | FC Hagen/Uthlede | - | SC Spelle-Venhaus | 0:3 | ||||
| 5. Round | 12/09/2021 | Heeslinger SC | - | SC Spelle-Venhaus | 2:1 | ||||
| 8. Round | 01/10/2021 | SC Spelle-Venhaus | - | TB Uphusen | 3:0 | ||||
| 9. Round | 10/10/2021 | TuS Bersenbrück | - | SC Spelle-Venhaus | 3:0 | ||||
| 12. Round | 31/10/2021 | SC Spelle-Venhaus | - | Kickers Emden | 2:1 | ||||
| 13. Round | 07/11/2021 | SC Spelle-Venhaus | - | FC Hagen/Uthlede | 5:2 | ||||
| 14. Round | 14/11/2021 | SC Spelle-Venhaus | - | Heeslinger SC | 2:0 |  |
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| 15. Round | 21/11/2021 | Blau-Weiß Lohne | - | SC Spelle-Venhaus | 1:1 |
Germany