| 1. Round | 14/08/2022 | SC Freiburg [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 2:0 | ||||
| 2. Round | 20/08/2022 | 1. FSV Mainz 05 [Youth B] | - | SpVgg Unterhaching [Youth B] | 1:0 | ||||
| 3. Round | 27/08/2022 | 1899 Hoffenheim [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 6:2 | ||||
| 6. Round | 18/09/2022 | 1. FC Saarbrücken [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 0:5 | ||||
| 9. Round | 29/10/2022 | 1. FSV Mainz 05 [Youth B] | - | 1. FC Nürnberg [Youth B] | 5:1 | ||||
| 10. Round | 05/11/2022 | Eintracht Frankfurt [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 4:2 |  |
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| 11. Round | 12/11/2022 | 1. FSV Mainz 05 [Youth B] | - | Jahn Regensburg [Youth B] | 0:2 | ||||
| 12. Round | 20/11/2022 | SpVgg Greuther Fürth [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 1:2 | |
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| 13. Round | 04/12/2022 | 1. FSV Mainz 05 [Youth B] | - | SV Darmstadt 98 [Youth B] | 0:1 | ||||
| 14. Round | 11/12/2022 | VfB Stuttgart [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 1:1 | ||||
| 15. Round | 26/02/2023 | 1. FSV Mainz 05 [Youth B] | - | TSV 1860 München [Youth B] | 0:3 | ||||
| 16. Round | 04/03/2023 | Bayern München [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 0:3 |
Germany
USA