| 1. Round | 04/08/1980 | SSV Ulm 1846 | - | Kickers Offenbach | 0:0 | ||||
| 2. Round | 08/08/1980 | Kickers Offenbach | - | SpVgg Bayreuth | 1:1 | ||||
| 3. Round | 14/08/1980 | SpVgg Fürth | - | Kickers Offenbach | 2:1 |  |
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| 4. Round | 18/08/1980 | Kickers Offenbach | - | 1. FC Saarbrücken | 5:1 | |
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| 5. Round | 21/08/1980 | FC 08 Homburg | - | Kickers Offenbach | 1:1 | ||||
| 7. Round | 04/09/1980 | FSV Frankfurt | - | Kickers Offenbach | 1:1 | ||||
| 8. Round | 11/09/1980 | Kickers Offenbach | - | SV Darmstadt 98 | 3:1 | |
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| 9. Round | 19/09/1980 | SC Freiburg | - | Kickers Offenbach | 4:1 | ||||
| 10. Round | 25/09/1980 | Kickers Offenbach | - | Hessen Kassel | 0:0 | ||||
| 11. Round | 10/10/1980 | FC Augsburg | - | Kickers Offenbach | 4:3 | ||||
| 12. Round | 17/10/1980 | Kickers Offenbach | - | VfB Eppingen | 5:1 | ||||
| 13. Round | 25/10/1980 | Eintracht Trier | - | Kickers Offenbach | 4:2 | ||||
| 14. Round | 30/10/1980 | Kickers Offenbach | - | Borussia Neunkirchen | 2:1 |
Germany