| 20. Round | 02/01/1981 | VfR Bürstadt | - | 1. FC Saarbrücken | 2:1 |  |
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| 21. Round | 09/01/1981 | FC 08 Homburg | - | VfR Bürstadt | 1:1 | ||||
| 23. Round | 23/01/1981 | FSV Frankfurt | - | VfR Bürstadt | 1:4 | ||||
| 24. Round | 06/02/1981 | VfR Bürstadt | - | SV Darmstadt 98 | 1:1 | ||||
| 25. Round | 13/02/1981 | SC Freiburg | - | VfR Bürstadt | 3:1 |  |
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| 26. Round | 20/02/1981 | VfR Bürstadt | - | Hessen Kassel | 2:0 | ||||
| 27. Round | 05/03/1981 | FC Augsburg | - | VfR Bürstadt | 1:2 | ||||
| 28. Round | 12/03/1981 | VfR Bürstadt | - | VfB Eppingen | 2:1 | ||||
| 29. Round | 20/03/1981 | Eintracht Trier | - | VfR Bürstadt | 0:1 | ||||
| 30. Round | 26/03/1981 | VfR Bürstadt | - | Borussia Neunkirchen | 4:1 | ||||
| 31. Round | 03/04/1981 | Waldhof Mannheim | - | VfR Bürstadt | 2:0 | |
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| 32. Round | 09/04/1981 | Stuttgarter Kickers | - | VfR Bürstadt | 3:1 | ||||
| 33. Round | 14/04/1981 | VfR Bürstadt | - | ESV Ingolstadt | 1:2 | |
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| 34. Round | 23/04/1981 | Kickers Offenbach | - | VfR Bürstadt | 6:1 | ||||
| 35. Round | 29/04/1981 | VfR Bürstadt | - | Freiburger FC | 4:1 | ||||
| 36. Round | 07/05/1981 | SSV Ulm 1846 | - | VfR Bürstadt | 3:0 | ||||
| 37. Round | 14/05/1981 | VfR Bürstadt | - | SpVgg Bayreuth | 1:3 | ||||
| 38. Round | 29/05/1981 | SpVgg Fürth | - | VfR Bürstadt | 0:1 |
Germany