| 17. Round | 22/01/2021 | VfL Osnabrück | - | Erzgebirge Aue | 0:1 | ||||
| 18. Round | 26/01/2021 | VfL Osnabrück | - | SpVgg Greuther Fürth | 0:1 | ||||
| 19. Round | 01/02/2021 | Hannover 96 | - | VfL Osnabrück | 1:0 | ||||
| 22. Round | 20/02/2021 | VfL Osnabrück | - | 1. FC Heidenheim 1846 | 1:2 | ||||
| 23. Round | 28/02/2021 | SV Sandhausen | - | VfL Osnabrück | 3:0 | ||||
| 25. Round | 14/03/2021 | 1. FC Nürnberg | - | VfL Osnabrück | 1:1 | ||||
| 26. Round | 21/03/2021 | VfL Osnabrück | - | FC St. Pauli | 1:2 | ||||
| 27. Round | 03/04/2021 | Karlsruher SC | - | VfL Osnabrück | 0:1 | ||||
| 28. Round | 11/04/2021 | VfL Osnabrück | - | Eintracht Braunschweig | 0:4 | ||||
| 30. Round | 21/04/2021 | SC Paderborn 07 | - | VfL Osnabrück | 2:2 |  |
Cameroon