| 1. Round | 25/07/2021 | Desna Chernigov | - | Chernomorets Odessa | 3:0 | ||||
| 2. Round | 01/08/2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 7. Round | 12/09/2021 | Vorskla Poltava | - | Desna Chernigov | 2:2 | ||||
| 8. Round | 17/09/2021 | Desna Chernigov | - | Rukh Lviv | 1:0 |  |
|||
| 10. Round | 03/10/2021 | Zorya Lugansk | - | Desna Chernigov | 2:0 | ||||
| 13. Round | 30/10/2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 |
Ukraine