| 2. Round | 05/09/2021 | 1. FC Köln [Women] | - | 1899 Hoffenheim [Women] | 1:2 | ||||
| 3. Round | 12/09/2021 | SGS Essen [Women] | - | 1899 Hoffenheim [Women] | 0:0 | ||||
| 4. Round | 02/10/2021 | 1899 Hoffenheim [Women] | - | Eintracht Frankfurt [Women] | 2:1 | ||||
| 5. Round | 09/10/2021 | Bayern München [Women] | - | 1899 Hoffenheim [Women] | 3:1 | ||||
| 7. Round | 07/11/2021 | FC Carl Zeiss Jena [Women] | - | 1899 Hoffenheim [Women] | 1:5 |  |
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| 9. Round | 21/11/2021 | Turbine Potsdam [Women] | - | 1899 Hoffenheim [Women] | 3:3 | ||||
| 12. Round | 18/12/2021 | SC Freiburg [Women] | - | 1899 Hoffenheim [Women] | 1:3 | ||||
| 14. Round | 13/02/2022 | 1899 Hoffenheim [Women] | - | SGS Essen [Women] | 2:1 | ||||
| 20. Round | 23/04/2022 | 1899 Hoffenheim [Women] | - | Turbine Potsdam [Women] | 1:2 | ||||
| 21. Round | 08/05/2022 | Werder Bremen [Women] | - | 1899 Hoffenheim [Women] | 0:1 | ||||
| 22. Round | 15/05/2022 | 1899 Hoffenheim [Women] | - | SC Sand [Women] | 3:3 |
Germany