| 4. Round | 12/09/2021 | VfL Wolfsburg II [Women] | - | 1899 Hoffenheim II [Women] | 0:0 | ||||
| 5. Round | 26/09/2021 | Bayern München II [Women] | - | VfL Wolfsburg II [Women] | 4:1 | ||||
| 14. Round | 27/02/2022 | RB Leipzig [Women] | - | VfL Wolfsburg II [Women] | 0:0 | ||||
| 15. Round | 06/03/2022 | VfL Wolfsburg II [Women] | - | MSV Duisburg [Women] | 0:2 | ||||
| 16. Round | 13/03/2022 | VfL Wolfsburg II [Women] | - | FSV Gütersloh 2009 [Women] | 1:3 | ||||
| 17. Round | 20/03/2022 | 1899 Hoffenheim II [Women] | - | VfL Wolfsburg II [Women] | 0:3 | ||||
| 18. Round | 10/04/2022 | VfL Wolfsburg II [Women] | - | Bayern München II [Women] | 0:1 | ||||
| 25. Round | 22/05/2022 | 1. FC Nürnberg [Women] | - | VfL Wolfsburg II [Women] | 3:3 | ||||
| 26. Round | 05/06/2022 | VfL Wolfsburg II [Women] | - | SV Henstedt-Ulzburg [Women] | 1:1 |
Austria