| 1. Round | 14/08/2022 | SpVgg Unterhaching [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:4 | ||||
| 3. Round | 27/08/2022 | 1899 Hoffenheim [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 6:2 | ||||
| 4. Round | 02/09/2022 | FC-Astoria Walldorf [Youth B] | - | 1899 Hoffenheim [Youth B] | 0:2 | ||||
| 5. Round | 10/09/2022 | 1899 Hoffenheim [Youth B] | - | 1. FC Saarbrücken [Youth B] | 6:0 | ||||
| 6. Round | 17/09/2022 | FC Augsburg [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:2 | ||||
| 7. Round | 01/10/2022 | 1899 Hoffenheim [Youth B] | - | Karlsruher SC [Youth B] | 3:1 | ||||
| 8. Round | 09/10/2022 | 1. FC Nürnberg [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:3 | ||||
| 9. Round | 29/10/2022 | 1899 Hoffenheim [Youth B] | - | Eintracht Frankfurt [Youth B] | 1:2 | ||||
| 11. Round | 12/11/2022 | 1899 Hoffenheim [Youth B] | - | SpVgg Greuther Fürth [Youth B] | 6:1 | ||||
| 12. Round | 19/11/2022 | SV Darmstadt 98 [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:7 | ||||
| 13. Round | 04/12/2022 | 1899 Hoffenheim [Youth B] | - | VfB Stuttgart [Youth B] | 2:8 | ||||
| 14. Round | 10/12/2022 | TSV 1860 München [Youth B] | - | 1899 Hoffenheim [Youth B] | 2:5 |
Germany