| 2. Round | 03/09/1950 | Preußen Dellbrück | - | Duisburger SpV | 1:0 | ||||
| 3. Round | 10/09/1950 | Duisburger SpV | - | Preußen Münster | 1:2 | ||||
| 4. Round | 17/09/1950 | SpVgg Erkenschwick | - | Duisburger SpV | 2:0 | ||||
| 5. Round | 24/09/1950 | Duisburger SpV | - | STV Horst-Emscher | 0:2 | ||||
| 6. Round | 01/10/1950 | Borussia VfL M.-Gladbach | - | Duisburger SpV | 0:1 | ||||
| 7. Round | 08/10/1950 | Duisburger SpV | - | Alemannia Aachen | 1:2 | ||||
| 8. Round | 15/10/1950 | SF Hamborn 07 | - | Duisburger SpV | 2:1 | ||||
| 9. Round | 22/10/1950 | Duisburger SpV | - | 1. FC Köln | 2:1 | ||||
| 10. Round | 29/10/1950 | FC Schalke 04 | - | Duisburger SpV | 3:0 | ||||
| 11. Round | 05/11/1950 | Duisburger SpV | - | DJK SF Katernberg | 1:3 | ||||
| 12. Round | 12/11/1950 | Borussia Dortmund | - | Duisburger SpV | 0:0 | ||||
| 13. Round | 19/11/1950 | Fortuna Düsseldorf | - | Duisburger SpV | 4:0 | ||||
| 14. Round | 26/11/1950 | Duisburger SpV | - | Rheydter SV | 0:0 | ||||
| 15. Round | 03/12/1950 | Duisburger SpV | - | Rot-Weiß Oberhausen | 2:0 | ||||
| 16. Round | 07/01/1951 | Rot-Weiss Essen | - | Duisburger SpV | 3:0 |
Germany