| 1. Round | 14/08/2021 | 1. FC Union Berlin [Youth] | - | FC Viktoria 1889 Berlin [Youth] | 0:0 | ||||
| 2. Round | 21/08/2021 | Hallescher FC [Youth] | - | 1. FC Union Berlin [Youth] | 1:3 | ||||
| 3. Round | 11/09/2021 | 1. FC Union Berlin [Youth] | - | VfL Wolfsburg [Youth] | 2:2 | ||||
| 4. Round | 19/09/2021 | Werder Bremen [Youth] | - | 1. FC Union Berlin [Youth] | 2:4 |  |
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| 5. Round | 25/09/2021 | 1. FC Union Berlin [Youth] | - | Hertha BSC [Youth] | 0:3 | ||||
| 6. Round | 02/10/2021 | 1. FC Magdeburg [Youth] | - | 1. FC Union Berlin [Youth] | 0:3 | ||||
| 9. Round | 31/10/2021 | Hansa Rostock [Youth] | - | 1. FC Union Berlin [Youth] | 1:1 | ||||
| 17. Round | 09/04/2022 | Chemnitzer FC [Youth] | - | 1. FC Union Berlin [Youth] | 0:2 | ||||
| 18. Round | 23/04/2022 | 1. FC Union Berlin [Youth] | - | Eimsbütteler TV [Youth] | 0:3 | ||||
| 19. Round | 30/04/2022 | Dynamo Dresden [Youth] | - | 1. FC Union Berlin [Youth] | 1:1 |
Germany