| 1. Round | 05/08/1980 | 1. FC Bocholt | - | SC Herford | 2:1 | ||||
| 2. Round | 08/08/1980 | SC Herford | - | TeBe Berlin | 2:1 | ||||
| 10. Round | 25/09/1980 | SC Herford | - | SpVgg Erkenschwick | 1:0 | ||||
| 11. Round | 30/09/1980 | SG Union Solingen | - | SC Herford | 0:0 | ||||
| 13. Round | 11/10/1980 | Hertha BSC | - | SC Herford | 3:1 | ||||
| 14. Round | 18/10/1980 | SC Herford | - | Rot-Weiss Essen | 1:3 | ||||
| 15. Round | 25/10/1980 | SC Herford | - | SC Göttingen 05 | 2:0 | ||||
| 16. Round | 30/10/1980 | Werder Bremen | - | SC Herford | 3:1 | ||||
| 17. Round | 07/11/1980 | SC Herford | - | Rot-Weiß Lüdenscheid | 3:1 |  |
|||
| 18. Round | 14/11/1980 | Hannover 96 | - | SC Herford | 3:2 |  |
|||
| 19. Round | 28/11/1980 | SC Herford | - | SG Wattenscheid 09 | 1:1 | ||||
| 20. Round | 05/12/1980 | VfL Osnabrück | - | SC Herford | 2:0 | |
|||
| 21. Round | 12/12/1980 | SC Herford | - | Rot-Weiß Oberhausen | 3:1 | ||||
| 22. Round | 02/01/1981 | SC Herford | - | 1. FC Bocholt | 0:2 | ||||
| 23. Round | 09/01/1981 | TeBe Berlin | - | SC Herford | 2:1 | ||||
| 25. Round | 23/01/1981 | SC Herford | - | VfL Osnabrück | 2:0 | ||||
| 26. Round | 06/02/1981 | Rot-Weiß Oberhausen | - | SC Herford | 2:1 |
Germany