| 1. Round | 06/08/2011 | Rot-Weiss Essen | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 2. Round | 13/08/2011 | 1. FSV Mainz 05 II | - | VfL Bochum II | 3:0 | ||||
| 3. Round | 20/08/2011 | Wuppertaler SV | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 4. Round | 27/08/2011 | 1. FSV Mainz 05 II | - | 1. FC Kaiserslautern II | 3:1 | ||||
| 5. Round | 30/08/2011 | Bayer Leverkusen II | - | 1. FSV Mainz 05 II | 0:3 | ||||
| 6. Round | 03/09/2011 | 1. FSV Mainz 05 II | - | Sportfreunde Lotte | 0:3 | ||||
| 7. Round | 09/09/2011 | Eintracht Trier | - | 1. FSV Mainz 05 II | 0:3 | ||||
| 34. Round | 20/04/2012 | 1. FC Köln II | - | 1. FSV Mainz 05 II | 1:0 | ||||
| 38. Round | 19/05/2012 | Bor. Mönchengladbach II | - | 1. FSV Mainz 05 II | 3:0 |
Germany