| 1. Round | 15/08/2021 | Lüneburger SK Hansa | - | VfV Hildesheim | 1:2 | ||||
| 2. Round | 22/08/2021 | VfV Hildesheim | - | SSV Jeddeloh II | 4:1 | ||||
| 3. Round | 28/08/2021 | Atlas Delmenhorst | - | VfV Hildesheim | 4:1 | ||||
| 4. Round | 05/09/2021 | VfV Hildesheim | - | VfB Oldenburg | 0:2 |  |
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| 5. Round | 11/09/2021 | Schwarz-Weiß Rehden | - | VfV Hildesheim | 3:0 | ||||
| 6. Round | 19/09/2021 | VfV Hildesheim | - | HSC Hannover | 3:1 |  |
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| 7. Round | 25/09/2021 | Werder Bremen II | - | VfV Hildesheim | 8:1 | ||||
| 8. Round | 03/10/2021 | VfV Hildesheim | - | FC Oberneuland | 3:0 | |
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| 9. Round | 10/10/2021 | Hannover 96 II | - | VfV Hildesheim | 2:1 | |
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| 10. Round | 17/10/2021 | VfV Hildesheim | - | Lüneburger SK Hansa | 1:1 | |
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| 11. Round | 23/10/2021 | SSV Jeddeloh II | - | VfV Hildesheim | 3:1 | |
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| 12. Round | 31/10/2021 | VfV Hildesheim | - | Atlas Delmenhorst | 2:1 | |
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| 13. Round | 07/11/2021 | VfB Oldenburg | - | VfV Hildesheim | 1:2 | |
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| 14. Round | 14/11/2021 | VfV Hildesheim | - | Schwarz-Weiß Rehden | 2:0 | ||||
| 15. Round | 21/11/2021 | HSC Hannover | - | VfV Hildesheim | 2:3 | ||||
| 16. Round | 28/11/2021 | VfV Hildesheim | - | Werder Bremen II | 1:2 | |
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| 18. Round | 12/12/2021 | VfV Hildesheim | - | Hannover 96 II | 2:2 |
Germany