| 1. Round | 11/09/2021 | VfL Bochum [Youth B] | - | Wuppertaler SV [Youth B] | 6:0 | ||||
| 2. Round | 18/09/2021 | Wuppertaler SV [Youth B] | - | Preußen Münster [Youth B] | 0:5 | ||||
| 3. Round | 25/09/2021 | Alemannia Aachen [Youth B] | - | Wuppertaler SV [Youth B] | 4:1 | ||||
| 4. Round | 03/10/2021 | Wuppertaler SV [Youth B] | - | Fortuna Köln [Youth B] | 1:2 |  |
|||
| 5. Round | 09/10/2021 | FC Hennef 05 [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 6. Round | 31/10/2021 | Wuppertaler SV [Youth B] | - | FC Schalke 04 [Youth B] | 1:7 | ||||
| 7. Round | 06/11/2021 | SC Paderborn 07 [Youth B] | - | Wuppertaler SV [Youth B] | 2:0 | ||||
| 11. Round | 19/02/2022 | Wuppertaler SV [Youth B] | - | SG Unterrath 12/24 [Youth B] | 1:1 | ||||
| 9. Round | 23/02/2022 | 1. FC Köln [Youth B] | - | Wuppertaler SV [Youth B] | 3:1 |
Germany