1st(1st leg) ACF Fiorentina - Slavia Praha 2:0 (1:0)
2nd (2nd leg) Slavia Praha - ACF Fiorentina 0:0 (0:0)
1st(1st leg): 12/08/2008 19:45 2nd (2nd leg): 27/08/2008 19:45 Winner: ACF Fiorentina
1st(1st leg) Spartak Moskva - Dinamo Kiev 1:4 (1:2)
2nd (2nd leg) Dinamo Kiev - Spartak Moskva 4:1 (2:0)
1st(1st leg): 13/08/2008 17:00 2nd (2nd leg): 27/08/2008 18:45 Winner: Dinamo Kiev
1st(1st leg) Shakhtar Donetsk - Dinamo Zagreb 2:0 (2:0)
2nd (2nd leg) Dinamo Zagreb - Shakhtar Donetsk 1:3 (0:1)
1st(1st leg): 13/08/2008 18:00 2nd (2nd leg): 27/08/2008 19:45 Winner: Shakhtar Donetsk
1st(1st leg) Levski Sofia - BATE Borisov 0:1 (0:0)
2nd (2nd leg) BATE Borisov - Levski Sofia 1:1 (1:1)
1st(1st leg): 13/08/2008 18:00 2nd (2nd leg): 27/08/2008 17:00 Winner: BATE Borisov
1st(1st leg) Anorthosis Famagusta - Olympiakos Piräus 3:0 (2:0)
2nd (2nd leg) Olympiakos Piräus - Anorthosis Famagusta 1:0 (0:0)
1st(1st leg): 13/08/2008 19:00 2nd (2nd leg): 27/08/2008 19:45 Winner: Anorthosis Famagusta
1st(1st leg) Aalborg BK - FBK Kaunas 2:0 (0:0)
2nd (2nd leg) FBK Kaunas - Aalborg BK 0:2 (0:0)
1st(1st leg): 13/08/2008 19:05 2nd (2nd leg): 27/08/2008 18:00 Winner: Aalborg BK
1st(1st leg) Galatasaray - FC Steaua Bucureşti 2:2 (1:2)
2nd (2nd leg) FC Steaua Bucureşti - Galatasaray 1:0 (0:0)
1st(1st leg): 13/08/2008 19:15 2nd (2nd leg): 27/08/2008 18:45 Winner: FC Steaua Bucureşti
1st(1st leg) FC Schalke 04 - Atlético Madrid 1:0 (1:0)
2nd (2nd leg) Atlético Madrid - FC Schalke 04 4:0 (1:0)
1st(1st leg): 13/08/2008 19:45 2nd (2nd leg): 27/08/2008 19:45 Winner: Atlético Madrid
1st(1st leg) FC Twente - Arsenal FC 0:2 (0:0)
2nd (2nd leg) Arsenal FC - FC Twente 4:0 (1:0)
1st(1st leg): 13/08/2008 19:45 2nd (2nd leg): 27/08/2008 20:05 Winner: Arsenal FC
1st(1st leg) Juventus - Artmedia Petržalka 4:0 (3:0)
2nd (2nd leg) Artmedia Petržalka - Juventus 1:1 (1:1)
1st(1st leg): 13/08/2008 19:45 2nd (2nd leg): 26/08/2008 19:45 Winner: Juventus
1st(1st leg) SK Brann - Olympique Marseille 0:1 (0:1)
2nd (2nd leg) Olympique Marseille - SK Brann 2:1 (0:0)
1st(1st leg): 13/08/2008 19:45 2nd (2nd leg): 27/08/2008 19:45 Winner: Olympique Marseille
1st(1st leg) Sparta Praha - Panathinaikos 1:2 (1:1)
2nd (2nd leg) Panathinaikos - Sparta Praha 1:0 (0:0)
1st(1st leg): 13/08/2008 19:45 2nd (2nd leg): 26/08/2008 19:45 Winner: Panathinaikos
1st(1st leg) Partizan - Fenerbahçe 2:2 (2:1)
2nd (2nd leg) Fenerbahçe - Partizan 2:1 (1:0)
1st(1st leg): 13/08/2008 20:00 2nd (2nd leg): 27/08/2008 19:00 Winner: Fenerbahçe
1st(1st leg) Standard Liège - Liverpool FC 0:0 (0:0)
2nd (2nd leg) Liverpool FC - Standard Liège 1:0 (0:0, 0:0) aet
1st(1st leg): 13/08/2008 20:05 2nd (2nd leg): 27/08/2008 20:05 Winner: Liverpool FC
1st(1st leg) Vitória Guimarães - FC Basel 0:0 (0:0)
2nd (2nd leg) FC Basel - Vitória Guimarães 2:1 (1:1)
1st(1st leg): 13/08/2008 20:30 2nd (2nd leg): 27/08/2008 19:15 Winner: FC Basel
1st(1st leg) FC Barcelona - Wisła Kraków 4:0 (2:0)
2nd (2nd leg) Wisła Kraków - FC Barcelona 1:0 (0:0)
1st(1st leg): 13/08/2008 21:00 2nd (2nd leg): 26/08/2008 19:45 Winner: FC Barcelona