1st(1st leg) Zenit St. Petersburg - AJ Auxerre 1:0 (1:0)
2nd (2nd leg) AJ Auxerre - Zenit St. Petersburg 2:0 (1:0)
1st(1st leg): 17/08/2010 17:30 2nd (2nd leg): 25/08/2010 19:45 Winner: AJ Auxerre
1st(1st leg) Rosenborg BK - FC København 2:1 (1:0)
2nd (2nd leg) FC København - Rosenborg BK 1:0 (1:0)
1st(1st leg): 17/08/2010 19:45 2nd (2nd leg): 25/08/2010 19:45 Winner: FC København
1st(1st leg) Sparta Praha - MŠK Žilina 0:2 (0:0)
2nd (2nd leg) MŠK Žilina - Sparta Praha 1:0 (1:0)
1st(1st leg): 17/08/2010 19:45 2nd (2nd leg): 25/08/2010 19:45 Winner: MŠK Žilina
1st(1st leg) BSC Young Boys - Tottenham Hotspur 3:2 (3:1)
2nd (2nd leg) Tottenham Hotspur - BSC Young Boys 4:0 (2:0)
1st(1st leg): 17/08/2010 19:45 2nd (2nd leg): 25/08/2010 19:45 Winner: Tottenham Hotspur
1st(1st leg) Dinamo Kiev - AFC Ajax 1:1 (0:0)
2nd (2nd leg) AFC Ajax - Dinamo Kiev 2:1 (1:0)
1st(1st leg): 17/08/2010 19:45 2nd (2nd leg): 25/08/2010 19:45 Winner: AFC Ajax
1st(1st leg) RB Salzburg - Hapoel Tel Aviv 2:3 (1:2)
2nd (2nd leg) Hapoel Tel Aviv - RB Salzburg 1:1 (0:1)
1st(1st leg): 18/08/2010 19:45 2nd (2nd leg): 24/08/2010 19:45 Winner: Hapoel Tel Aviv
1st(1st leg) FC Basel - FC Sheriff 1:0 (0:0)
2nd (2nd leg) FC Sheriff - FC Basel 0:3 (0:0)
1st(1st leg): 18/08/2010 19:45 2nd (2nd leg): 24/08/2010 19:45 Winner: FC Basel
1st(1st leg) Partizan - RSC Anderlecht 2:2 (0:0)
2nd (2nd leg) RSC Anderlecht - Partizan 2:3 (0:1, 2:2, 2:2) pso
1st(1st leg): 18/08/2010 19:45 2nd (2nd leg): 24/08/2010 19:45 Winner: Partizan
1st(1st leg) Sporting Braga - Sevilla FC 1:0 (0:0)
2nd (2nd leg) Sevilla FC - Sporting Braga 3:4 (0:1)
1st(1st leg): 18/08/2010 19:45 2nd (2nd leg): 24/08/2010 19:45 Winner: Sporting Braga
1st(1st leg) Werder Bremen - Sampdoria 3:1 (0:0)
2nd (2nd leg) Sampdoria - Werder Bremen 3:2 (2:0, 3:1) aet
1st(1st leg): 18/08/2010 19:45 2nd (2nd leg): 24/08/2010 19:45 Winner: Werder Bremen