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| 1st(1st leg) | FK Bodø/Glimt | - | Dinamo Zagreb | 1:0 (1:0) | ||
| 2nd (2nd leg) | Dinamo Zagreb | - | FK Bodø/Glimt | 4:1 (2:0, 2:1) aet | ||
| 1st(1st leg): 16/08/2022 20:00 | 2nd (2nd leg): 24/08/2022 20:00 | Winner: Dinamo Zagreb | ||||
| 1st(1st leg) | FC København | - | Trabzonspor | 2:1 (1:0) | ||
| 2nd (2nd leg) | Trabzonspor | - | FC København | 0:0 (0:0) | ||
| 1st(1st leg): 16/08/2022 20:00 | 2nd (2nd leg): 24/08/2022 20:00 | Winner: FC København | ||||
| 1st(1st leg) | Rangers FC | - | PSV Eindhoven | 2:2 (1:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Rangers FC | 0:1 (0:0) | ||
| 1st(1st leg): 16/08/2022 20:00 | 2nd (2nd leg): 24/08/2022 20:00 | Winner: Rangers FC | ||||
| 1st(1st leg) | Qarabağ FK | - | Viktoria Plzeň | 0:0 (0:0) | ||
| 2nd (2nd leg) | Viktoria Plzeň | - | Qarabağ FK | 2:1 (0:1) | ||
| 1st(1st leg): 17/08/2022 17:45 | 2nd (2nd leg): 23/08/2022 20:00 | Winner: Viktoria Plzeň | ||||
| 1st(1st leg) | Maccabi Haifa | - | Crvena Zvezda | 3:2 (1:2) | ||
| 2nd (2nd leg) | Crvena Zvezda | - | Maccabi Haifa | 2:2 (2:1) | ||
| 1st(1st leg): 17/08/2022 20:00 | 2nd (2nd leg): 23/08/2022 20:00 | Winner: Maccabi Haifa | ||||
| 1st(1st leg) | Dinamo Kiev | - | SL Benfica | 0:2 (0:2) | ||
| 2nd (2nd leg) | SL Benfica | - | Dinamo Kiev | 3:0 (3:0) | ||
| 1st(1st leg): 17/08/2022 20:00 | 2nd (2nd leg): 23/08/2022 20:00 | Winner: SL Benfica | ||||
