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| 1st(1st leg) | AZ Alkmaar | - | Tottenham Hotspur | 1:0 (1:0) | ||
| 2nd (2nd leg) | Tottenham Hotspur | - | AZ Alkmaar | 3:1 (1:0) | ||
| 1st(1st leg): 06/03/2025 17:45 | 2nd (2nd leg): 13/03/2025 20:00 | Winner: Tottenham Hotspur | ||||
| 1st(1st leg) | Real Sociedad | - | Manchester United | 1:1 (0:0) | ||
| 2nd (2nd leg) | Manchester United | - | Real Sociedad | 4:1 (1:1) | ||
| 1st(1st leg): 06/03/2025 17:45 | 2nd (2nd leg): 13/03/2025 20:00 | Winner: Manchester United | ||||
| 1st(1st leg) | FCSB | - | Olympique Lyonnais | 1:3 (0:1) | ||
| 2nd (2nd leg) | Olympique Lyonnais | - | FCSB | 4:0 (2:0) | ||
| 1st(1st leg): 06/03/2025 17:45 | 2nd (2nd leg): 13/03/2025 20:00 | Winner: Olympique Lyonnais | ||||
| 1st(1st leg) | Fenerbahçe | - | Rangers FC | 1:3 (1:2) | ||
| 2nd (2nd leg) | Rangers FC | - | Fenerbahçe | 3:2 (0:1, 0:2, 0:2) pso | ||
| 1st(1st leg): 06/03/2025 17:45 | 2nd (2nd leg): 13/03/2025 20:00 | Winner: Rangers FC | ||||
| 1st(1st leg) | AS Roma | - | Athletic Club | 2:1 (0:0) | ||
| 2nd (2nd leg) | Athletic Club | - | AS Roma | 3:1 (1:0) | ||
| 1st(1st leg): 06/03/2025 20:00 | 2nd (2nd leg): 13/03/2025 17:45 | Winner: Athletic Club | ||||
| 1st(1st leg) | FK Bodø/Glimt | - | Olympiakos Piraeus | 3:0 (2:0) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | FK Bodø/Glimt | 2:1 (0:1) | ||
| 1st(1st leg): 06/03/2025 20:00 | 2nd (2nd leg): 13/03/2025 17:45 | Winner: FK Bodø/Glimt | ||||
| 1st(1st leg) | AFC Ajax | - | Eintracht Frankfurt | 1:2 (1:1) | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | AFC Ajax | 4:1 (2:0) | ||
| 1st(1st leg): 06/03/2025 20:00 | 2nd (2nd leg): 13/03/2025 17:45 | Winner: Eintracht Frankfurt | ||||
| 1st(1st leg) | Viktoria Plzeň | - | Lazio Roma | 1:2 (0:1) | ||
| 2nd (2nd leg) | Lazio Roma | - | Viktoria Plzeň | 1:1 (0:0) | ||
| 1st(1st leg): 06/03/2025 20:00 | 2nd (2nd leg): 13/03/2025 17:45 | Winner: Lazio Roma | ||||
