1st(1st leg) Beitar Jerusalem - AS Saint-Étienne 1:2 (1:2)
2nd (2nd leg) AS Saint-Étienne - Beitar Jerusalem 0:0 (0:0)
1st(1st leg): 17/08/2016 17:00 2nd (2nd leg): 25/08/2016 19:45 Winner: AS Saint-Étienne
1st(1st leg) FK Astana - BATE Borisov 2:0 (0:0)
2nd (2nd leg) BATE Borisov - FK Astana 2:2 (1:0)
1st(1st leg): 18/08/2016 15:00 2nd (2nd leg): 25/08/2016 19:00 Winner: FK Astana
1st(1st leg) Dinamo Tbilisi - PAOK Saloniki 0:3 (0:1)
2nd (2nd leg) PAOK Saloniki - Dinamo Tbilisi 2:0 (2:0)
1st(1st leg): 18/08/2016 17:00 2nd (2nd leg): 25/08/2016 19:00 Winner: PAOK Saloniki
1st(1st leg) SønderjyskE - Sparta Praha 0:0 (0:0)
2nd (2nd leg) Sparta Praha - SønderjyskE 3:2 (1:2)
1st(1st leg): 18/08/2016 17:15 2nd (2nd leg): 25/08/2016 19:00 Winner: Sparta Praha
1st(1st leg) FC Midtjylland - Osmanlıspor FK 0:1 (0:1)
2nd (2nd leg) Osmanlıspor FK - FC Midtjylland 2:0 (1:0)
1st(1st leg): 18/08/2016 17:30 2nd (2nd leg): 25/08/2016 19:00 Winner: Osmanlıspor FK
1st(1st leg) FK Krasnodar - FK Partizani 4:0 (3:0)
2nd (2nd leg) FK Partizani - FK Krasnodar 0:0 (0:0)
1st(1st leg): 18/08/2016 17:30 2nd (2nd leg): 25/08/2016 18:30 Winner: FK Krasnodar
1st(1st leg) AEK Larnaca - Slovan Liberec 0:1 (0:1)
2nd (2nd leg) Slovan Liberec - AEK Larnaca 3:0 (3:0)
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 18:00 Winner: Slovan Liberec
1st(1st leg) Austria Wien - Rosenborg BK 2:1 (0:0)
2nd (2nd leg) Rosenborg BK - Austria Wien 1:2 (0:0)
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 18:00 Winner: Austria Wien
1st(1st leg) Gabala FK - NK Maribor 3:1 (1:1)
2nd (2nd leg) NK Maribor - Gabala FK 1:0 (0:0)
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 19:15 Winner: Gabala FK
1st(1st leg) Slavia Praha - RSC Anderlecht 0:3 (0:0)
2nd (2nd leg) RSC Anderlecht - Slavia Praha 3:0 (2:0)
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 19:00 Winner: RSC Anderlecht
1st(1st leg) IFK Göteborg - Qarabağ FK 1:0 (0:0)
2nd (2nd leg) Qarabağ FK - IFK Göteborg 3:0 (2:0)
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 17:30 Winner: Qarabağ FK
1st(1st leg) Maccabi Tel Aviv - Hajduk Split 2:1 (1:0)
2nd (2nd leg) Hajduk Split - Maccabi Tel Aviv 3:4 (1:0, 2:1, 2:1) pso
1st(1st leg): 18/08/2016 18:00 2nd (2nd leg): 25/08/2016 19:30 Winner: Maccabi Tel Aviv
1st(1st leg) İstanbul Başakşehir - Shakhtar Donetsk 1:2 (0:2)
2nd (2nd leg) Shakhtar Donetsk - İstanbul Başakşehir 2:0 (1:0)
1st(1st leg): 18/08/2016 18:30 2nd (2nd leg): 25/08/2016 20:00 Winner: Shakhtar Donetsk
1st(1st leg) Lokomotiva Zagreb - KRC Genk 2:2 (0:1)
2nd (2nd leg) KRC Genk - Lokomotiva Zagreb 2:0 (1:0)
1st(1st leg): 18/08/2016 19:00 2nd (2nd leg): 25/08/2016 19:00 Winner: KRC Genk
1st(1st leg) Vojvodina - AZ Alkmaar 0:3 (0:2)
2nd (2nd leg) AZ Alkmaar - Vojvodina 0:0 (0:0)
1st(1st leg): 18/08/2016 19:00 2nd (2nd leg): 25/08/2016 19:00 Winner: AZ Alkmaar
1st(1st leg) Fenerbahçe - Grasshopper Club Zürich 3:0 (1:0)
2nd (2nd leg) Grasshopper Club Zürich - Fenerbahçe 0:2 (0:0)
1st(1st leg): 18/08/2016 19:00 2nd (2nd leg): 25/08/2016 18:00 Winner: Fenerbahçe
1st(1st leg) Panathinaikos - Brøndby IF 3:0 (1:0)
2nd (2nd leg) Brøndby IF - Panathinaikos 1:1 (1:0)
1st(1st leg): 18/08/2016 19:00 2nd (2nd leg): 25/08/2016 18:00 Winner: Panathinaikos
1st(1st leg) Astra Giurgiu - West Ham United 1:1 (0:1)
2nd (2nd leg) West Ham United - Astra Giurgiu 0:1 (0:1)
1st(1st leg): 18/08/2016 19:15 2nd (2nd leg): 25/08/2016 19:45 Winner: Astra Giurgiu
1st(1st leg) KAA Gent - KF Shkëndija 79 2:1 (1:1)
2nd (2nd leg) KF Shkëndija 79 - KAA Gent 0:4 (0:0)
1st(1st leg): 18/08/2016 19:30 2nd (2nd leg): 25/08/2016 19:00 Winner: KAA Gent
1st(1st leg) Sassuolo Calcio - Crvena Zvezda 3:0 (2:0)
2nd (2nd leg) Crvena Zvezda - Sassuolo Calcio 1:1 (0:1)
1st(1st leg): 18/08/2016 19:45 2nd (2nd leg): 25/08/2016 19:30 Winner: Sassuolo Calcio
1st(1st leg) FC Arouca - Olympiakos Piräus 0:1 (0:1)
2nd (2nd leg) Olympiakos Piräus - FC Arouca 2:1 (0:0, 0:1) aet
1st(1st leg): 18/08/2016 20:00 2nd (2nd leg): 25/08/2016 19:45 Winner: Olympiakos Piräus
1st(1st leg) FK AS Trenčín - Rapid Wien 0:4 (0:1)
2nd (2nd leg) Rapid Wien - FK AS Trenčín 0:2 (0:2)
1st(1st leg): 18/08/2016 20:05 2nd (2nd leg): 25/08/2016 20:05 Winner: Rapid Wien