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| 1st(1st leg) | Lillestrøm SK | - | 1. FFC Frankfurt | 0:2 (0:1) | ||
| 2nd (2nd leg) | 1. FFC Frankfurt | - | Lillestrøm SK | 5:4 (0:1, 0:2, 0:2) pso | ||
| 1st(1st leg): 11/11/2015 17:00 | 2nd (2nd leg): 18/11/2015 17:00 | Winner: 1. FFC Frankfurt | ||||
| 1st(1st leg) | FC Twente | - | FC Barcelona | 0:1 (0:0) | ||
| 2nd (2nd leg) | FC Barcelona | - | FC Twente | 1:0 (1:0) | ||
| 1st(1st leg): 11/11/2015 18:00 | 2nd (2nd leg): 18/11/2015 18:00 | Winner: FC Barcelona | ||||
| 1st(1st leg) | KIF Örebro DFF | - | Paris Saint-Germain | 1:1 (1:0) | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | KIF Örebro DFF | 0:0 (0:0) | ||
| 1st(1st leg): 11/11/2015 18:00 | 2nd (2nd leg): 18/11/2015 19:00 | Winner: Paris Saint-Germain | ||||
| 1st(1st leg) | Atlético Madrid | - | Olympique Lyonnais | 1:3 (0:2) | ||
| 2nd (2nd leg) | Olympique Lyonnais | - | Atlético Madrid | 6:0 (3:0) | ||
| 1st(1st leg): 11/11/2015 19:00 | 2nd (2nd leg): 18/11/2015 17:00 | Winner: Olympique Lyonnais | ||||
| 1st(1st leg) | Chelsea LFC | - | VfL Wolfsburg | 1:2 (0:1) | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | Chelsea LFC | 2:0 (1:0) | ||
| 1st(1st leg): 11/11/2015 19:00 | 2nd (2nd leg): 18/11/2015 15:00 | Winner: VfL Wolfsburg | ||||
| 1st(1st leg) | ACF Brescia | - | Fortuna Hjørring | 1:0 (1:0) | ||
| 2nd (2nd leg) | Fortuna Hjørring | - | ACF Brescia | 1:1 (0:0) | ||
| 1st(1st leg): 11/11/2015 19:30 | 2nd (2nd leg): 18/11/2015 18:00 | Winner: ACF Brescia | ||||
| 1st(1st leg) | Slavia Praha | - | Zvezda 2005 Perm | 2:1 (1:1) | ||
| 2nd (2nd leg) | Zvezda 2005 Perm | - | Slavia Praha | 0:0 (0:0) | ||
| 1st(1st leg): 12/11/2015 17:30 | 2nd (2nd leg): 19/11/2015 14:00 | Winner: Slavia Praha | ||||
| 1st(1st leg) | AGSM Verona | - | FC Rosengård | 1:3 (1:2) | ||
| 2nd (2nd leg) | FC Rosengård | - | AGSM Verona | 5:1 (1:1) | ||
| 1st(1st leg): 12/11/2015 19:30 | 2nd (2nd leg): 19/11/2015 18:00 | Winner: FC Rosengård | ||||
