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| 1st(1st leg) | Apollon Limassol | - | WFC Zhytlobud-1 Kharkiv | 1:2 (1:1) | ||
| 2nd (2nd leg) | WFC Zhytlobud-1 Kharkiv | - | Apollon Limassol | 3:1 (2:0) | ||
| 1st(1st leg): 31/08/2021 16:00 | 2nd (2nd leg): 09/09/2021 16:00 | Winner: WFC Zhytlobud-1 Kharkiv | ||||
| 1st(1st leg) | FC Rosengård | - | 1899 Hoffenheim | 0:3 (0:1) | ||
| 2nd (2nd leg) | 1899 Hoffenheim | - | FC Rosengård | 3:3 (2:1) | ||
| 1st(1st leg): 31/08/2021 18:00 | 2nd (2nd leg): 08/09/2021 18:00 | Winner: 1899 Hoffenheim | ||||
| 1st(1st leg) | FC Twente | - | SL Benfica | 1:1 (1:1) | ||
| 2nd (2nd leg) | SL Benfica | - | FC Twente | 4:0 (1:0) | ||
| 1st(1st leg): 31/08/2021 18:30 | 2nd (2nd leg): 09/09/2021 19:00 | Winner: SL Benfica | ||||
| 1st(1st leg) | Arsenal WFC | - | Slavia Praha | 3:0 (2:0) | ||
| 2nd (2nd leg) | Slavia Praha | - | Arsenal WFC | 0:4 (0:0) | ||
| 1st(1st leg): 31/08/2021 19:30 | 2nd (2nd leg): 09/09/2021 17:30 | Winner: Arsenal WFC | ||||
| 1st(1st leg) | Real Madrid | - | Manchester City WFC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Manchester City WFC | - | Real Madrid | 0:1 (0:1) | ||
| 1st(1st leg): 31/08/2021 20:00 | 2nd (2nd leg): 08/09/2021 19:00 | Winner: Real Madrid | ||||
| 1st(1st leg) | AC Sparta Praha | - | HB Køge | 0:1 (0:0) | ||
| 2nd (2nd leg) | HB Køge | - | AC Sparta Praha | 2:0 (0:0) | ||
| 1st(1st leg): 01/09/2021 17:00 | 2nd (2nd leg): 08/09/2021 17:00 | Winner: HB Køge | ||||
| 1st(1st leg) | VfL Wolfsburg | - | Girondins Bordeaux | 3:2 (2:1) | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | VfL Wolfsburg | 0:3 (1:1, 2:1, 3:2) pso | ||
| 1st(1st leg): 01/09/2021 17:00 | 2nd (2nd leg): 08/09/2021 18:00 | Winner: VfL Wolfsburg | ||||
| 1st(1st leg) | ŽNK Osijek | - | Breiðablik | 1:1 (1:1) | ||
| 2nd (2nd leg) | Breiðablik | - | ŽNK Osijek | 3:0 (2:0) | ||
| 1st(1st leg): 01/09/2021 17:00 | 2nd (2nd leg): 09/09/2021 18:00 | Winner: Breiðablik | ||||
| 1st(1st leg) | FK Vllaznia | - | Juventus | 0:2 (0:2) | ||
| 2nd (2nd leg) | Juventus | - | FK Vllaznia | 1:0 (1:0) | ||
| 1st(1st leg): 01/09/2021 18:00 | 2nd (2nd leg): 09/09/2021 19:00 | Winner: Juventus | ||||
| 1st(1st leg) | Vålerenga IF | - | BK Häcken | 1:3 (0:2) | ||
| 2nd (2nd leg) | BK Häcken | - | Vålerenga IF | 3:2 (1:0) | ||
| 1st(1st leg): 01/09/2021 18:00 | 2nd (2nd leg): 08/09/2021 18:00 | Winner: BK Häcken | ||||
| 1st(1st leg) | Servette FCCF | - | Glasgow City FC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Glasgow City FC | - | Servette FCCF | 1:2 (1:1) | ||
| 1st(1st leg): 01/09/2021 18:15 | 2nd (2nd leg): 08/09/2021 15:10 | Winner: Servette FCCF | ||||
| 1st(1st leg) | Levante UD | - | Olympique Lyon | 1:2 (0:0) | ||
| 2nd (2nd leg) | Olympique Lyon | - | Levante UD | 2:1 (0:0) | ||
| 1st(1st leg): 01/09/2021 20:00 | 2nd (2nd leg): 08/09/2021 17:00 | Winner: Olympique Lyon | ||||
