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| 1st(1st leg) | Bayern München | - | FC Schalke 04 | 2:0 | ||
| 2nd (2nd leg) | FC Schalke 04 | - | Bayern München | 1:2 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: Bayern München | ||||
| 1st(1st leg) | BFC Meteor Berlin | - | KBC Duisburg | 0:2 | ||
| 2nd (2nd leg) | KBC Duisburg | - | BFC Meteor Berlin | 3:1 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: KBC Duisburg | ||||
| 1st(1st leg) | FSV Frankfurt | - | SSG Bergisch Gladbach | 0:4 | ||
| 2nd (2nd leg) | SSG Bergisch Gladbach | - | FSV Frankfurt | 5:0 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: SSG Bergisch Gladbach | ||||
| 1st(1st leg) | TuS Niederkirchen | - | Hellas Marpingen | 1:0 | ||
| 2nd (2nd leg) | Hellas Marpingen | - | TuS Niederkirchen | 1:2 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: TuS Niederkirchen | ||||
| 1st(1st leg) | VfL Schorndorf | - | VfL Wittekind Wildeshausen | 1:0 | ||
| 2nd (2nd leg) | VfL Wittekind Wildeshausen | - | VfL Schorndorf | 3:0 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: VfL Wittekind Wildeshausen | ||||
| 1st(1st leg) | FSV Harburg | - | SC 1922 Lauchringen | 5:2 | ||
| 2nd (2nd leg) | SC 1922 Lauchringen | - | FSV Harburg | 0:2 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: FSV Harburg | ||||
| 1st(1st leg) | TSV Wulsdorf | - | SC 07 Bad Neuenahr | 0:2 | ||
| 2nd (2nd leg) | SC 07 Bad Neuenahr | - | TSV Wulsdorf | 11:0 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: SC 07 Bad Neuenahr | ||||
| 1st(1st leg) | Rendsburger TSV | - | SV Schlierstadt | 0:5 | ||
| 2nd (2nd leg) | SV Schlierstadt | - | Rendsburger TSV | 6:2 | ||
| 1st(1st leg): 11/05/1980 | 2nd (2nd leg): 15/05/1980 | Winner: SV Schlierstadt | ||||
