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| 1st(1st leg) | VfL Schorndorf | - | TSV Wulsdorf | 6:0 | ||
| 2nd (2nd leg) | TSV Wulsdorf | - | VfL Schorndorf | 0:5 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 24/05/1981 | Winner: VfL Schorndorf | ||||
| 1st(1st leg) | SFD 75 Düsseldorf | - | VfL Wittekind Wildeshausen | 5:3 | ||
| 2nd (2nd leg) | VfL Wittekind Wildeshausen | - | SFD 75 Düsseldorf | 2:1 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 23/05/1981 | Winner: SFD 75 Düsseldorf | ||||
| 1st(1st leg) | FSV Harburg | - | TeBe Berlin | 2:2 | ||
| 2nd (2nd leg) | TeBe Berlin | - | FSV Harburg | 6:1 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 24/05/1981 | Winner: TeBe Berlin | ||||
| 1st(1st leg) | SC 07 Bad Neuenahr | - | SC Freiburg | 3:1 | ||
| 2nd (2nd leg) | SC Freiburg | - | SC 07 Bad Neuenahr | 1:0 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 24/05/1981 | Winner: SC 07 Bad Neuenahr | ||||
| 1st(1st leg) | FC Schalke 04 | - | TuS Wörrstadt | 0:1 | ||
| 2nd (2nd leg) | TuS Wörrstadt | - | FC Schalke 04 | 4:0 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 23/05/1981 | Winner: TuS Wörrstadt | ||||
| 1st(1st leg) | SV Schlierstadt | - | SV Weiskirchen | 3:0 | ||
| 2nd (2nd leg) | SV Weiskirchen | - | SV Schlierstadt | 0:4 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 24/05/1981 | Winner: SV Schlierstadt | ||||
| 1st(1st leg) | FSV Frankfurt | - | Rendsburger TSV | 3:0 | ||
| 2nd (2nd leg) | Rendsburger TSV | - | FSV Frankfurt | 0:5 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 24/05/1981 | Winner: FSV Frankfurt | ||||
| 1st(1st leg) | SSG Bergisch Gladbach | - | Bayern München | 3:0 | ||
| 2nd (2nd leg) | Bayern München | - | SSG Bergisch Gladbach | 1:0 | ||
| 1st(1st leg): 17/05/1981 | 2nd (2nd leg): 23/05/1981 | Winner: SSG Bergisch Gladbach | ||||
