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| 10/09/2022 | 17:00 | Fortuna Köln | - | SC Sand | 0:1 (0:0) | |
| 11/09/2022 | 12:00 | ATS Buntentor | - | SGS Essen | 1:6 (1:2) | |
| 12:00 | Magdeburger FFC | - | MSV Duisburg | 0:5 (0:2) | ||
| 12:00 | Borussia Bocholt | - | FC Carl Zeiss Jena | 1:2 (0:1) | ||
| 12:00 | SV 67 Weinberg | - | Eintracht Frankfurt | 0:7 (0:3) | ||
| 13:00 | SV Henstedt-Ulzburg | - | Werder Bremen | 0:3 (0:1) | ||
| 13:00 | FSV Gütersloh 2009 | - | VfL Wolfsburg | 2:8 (1:3) | ||
| 13:00 | VfL Bochum | - | SV Meppen | 0:1 (0:1) | ||
| 13:00 | Türkiyemspor Berlin | - | RB Leipzig | 0:6 (0:3) | ||
| 13:00 | TSV Jahn Calden | - | Bayer Leverkusen | 1:4 (0:2) | ||
| 13:00 | SV 07 Elversberg | - | 1. FC Köln | 0:8 (0:3) | ||
| 13:00 | SG 99 Andernach | - | SC Freiburg | 2:3 (0:0, 1:1) aet | ||
| 13:00 | Karlsruher SC | - | 1. FC Nürnberg | 1:2 (0:1) | ||
| 15:00 | FC Viktoria 1889 Berlin | - | Turbine Potsdam | 2:3 (0:2, 3:3, 4:4) pso | ||
| 15:00 | 1. FC Saarbrücken | - | 1899 Hoffenheim | 1:7 (0:3) | ||
| 12/09/2022 | 17:30 | FC Ingolstadt 04 | - | Bayern München | 0:7 (0:4) |
