| 1. Round | 10/04/2022 | FCE Rheine | - | SC Paderborn 07 II | 2:0 | ||||
| 2. Round | 18/04/2022 | SC Paderborn 07 II | - | SV Schermbeck | 1:0 |  |
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| 4. Round | 30/04/2022 | SC Paderborn 07 II | - | Westfalia Rhynern | 0:0 | ||||
| 5. Round | 08/05/2022 | SG Wattenscheid 09 | - | SC Paderborn 07 II | 2:1 | ||||
| 6. Round | 15/05/2022 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 |
Togo