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| 15/05/2022 | 14:00 | ASC 09 Dortmund | - | SG Wattenscheid 09 | 2:3 (1:0) | |
| 14:00 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 (1:1) | ||
| 14:00 | FCE Rheine | - | SV Schermbeck | 0:0 (0:0) | ||
| 14:00 | Sportfreunde Siegen | - | Westfalia Rhynern | 1:5 (1:3) | ||
| 15:00 | TuS Erndtebrück | - | 1. FC Kaan-Marienborn | 1:6 (0:1) |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Kaan-Marienborn | 26 | 17 | 7 | 2 | 69:26 | 43 | 58 |
| 2 |
|
Westfalia Rhynern | 26 | 17 | 2 | 7 | 64:27 | 37 | 53 |
| 3 |
|
SG Wattenscheid 09 | 26 | 16 | 4 | 6 | 46:28 | 18 | 52 |
| 4 |
|
SC Paderborn 07 II | 26 | 15 | 6 | 5 | 63:27 | 36 | 51 |
| 5 |
|
FC Gütersloh | 26 | 14 | 8 | 4 | 39:18 | 21 | 50 |
| 6 |
|
ASC 09 Dortmund | 26 | 12 | 6 | 8 | 59:50 | 9 | 42 |
| 7 |
|
FCE Rheine | 26 | 12 | 4 | 10 | 42:42 | 0 | 40 |
| 8 |
|
TuS Erndtebrück | 26 | 12 | 4 | 10 | 43:52 | -9 | 40 |
| 9 |
|
SV Schermbeck | 26 | 11 | 3 | 12 | 40:35 | 5 | 36 |
| 10 |
|
Sportfreunde Siegen | 26 | 9 | 9 | 8 | 42:48 | -6 | 36 |
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