| 2. Round | 12/09/2020 | Fortuna Köln | - | SV 19 Straelen | 3:0 | ||||
| 4. Round | 19/09/2020 | Fortuna Köln | - | Wuppertaler SV | 3:2 | ||||
| 8. Round | 10/10/2020 | Fortuna Köln | - | Rot-Weiss Essen | 1:1 | ||||
| 10. Round | 21/10/2020 | Fortuna Köln | - | Bonner SC | 4:1 | ||||
| 5. Round | 18/11/2020 | Alemannia Aachen | - | Fortuna Köln | 0:1 | ||||
| 16. Round | 21/11/2020 | Fortuna Köln | - | FC Wegberg-Beeck | 2:2 | ||||
| 17. Round | 25/11/2020 | Fortuna Köln | - | Preußen Münster | 2:0 | ||||
| 18. Round | 28/11/2020 | Bor. Mönchengladbach II | - | Fortuna Köln | 0:0 | ||||
| 20. Round | 12/12/2020 | FC Schalke 04 II | - | Fortuna Köln | 1:1 | ||||
| 13. Round | 16/12/2020 | Rot Weiss Ahlen | - | Fortuna Köln | 0:3 | ||||
| 26. Round | 24/03/2021 | Fortuna Köln | - | Alemannia Aachen | 2:2 | ||||
| 33. Round | 04/04/2021 | Borussia Dortmund II | - | Fortuna Köln | 1:0 | ||||
| 35. Round | 10/04/2021 | Fortuna Köln | - | SV Lippstadt 08 | 1:0 | ||||
| 36. Round | 04/05/2021 | Fortuna Köln | - | Fortuna Düsseldorf II | 2:0 | ||||
| 38. Round | 08/05/2021 | Preußen Münster | - | Fortuna Köln | 3:1 | ||||
| 39. Round | 15/05/2021 | Fortuna Köln | - | Bor. Mönchengladbach II | 0:1 |  |
|||
| 41. Round | 29/05/2021 | Fortuna Köln | - | FC Schalke 04 II | 4:1 |
Germany