| 1. Round | 14/08/2021 | 1899 Hoffenheim [Youth B] | - | SV Darmstadt 98 [Youth B] | 4:1 | ||||
| 2. Round | 22/08/2021 | SV Darmstadt 98 [Youth B] | - | Karlsruher SC [Youth B] | 2:1 | ||||
| 4. Round | 11/09/2021 | SV Darmstadt 98 [Youth B] | - | SV 07 Elversberg [Youth B] | 3:1 | ||||
| 5. Round | 18/09/2021 | VfB Stuttgart [Youth B] | - | SV Darmstadt 98 [Youth B] | 3:1 |  |
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| 6. Round | 26/09/2021 | SV Darmstadt 98 [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 3:2 | ||||
| 7. Round | 03/10/2021 | SpVgg Unterhaching [Youth B] | - | SV Darmstadt 98 [Youth B] | 4:0 | ||||
| 8. Round | 10/10/2021 | SV Darmstadt 98 [Youth B] | - | FSV Frankfurt [Youth B] | 0:2 | ||||
| 9. Round | 31/10/2021 | 1. FC Nürnberg [Youth B] | - | SV Darmstadt 98 [Youth B] | 6:2 |  |
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| 10. Round | 06/11/2021 | SV Darmstadt 98 [Youth B] | - | Bayern München [Youth B] | 1:3 | ||||
| 11. Round | 20/11/2021 | Stuttgarter Kickers [Youth B] | - | SV Darmstadt 98 [Youth B] | 0:2 | ||||
| 12. Round | 28/11/2021 | SV Darmstadt 98 [Youth B] | - | FC Augsburg [Youth B] | 1:0 | |
Germany