| Group B | 29/09/2010 | FC Schalke 04 | - | SL Benfica | 2:0 | ||||
| Group B | 20/10/2010 | FC Schalke 04 | - | Hapoel Tel Aviv | 3:1 | ||||
| Group B | 02/11/2010 | Hapoel Tel Aviv | - | FC Schalke 04 | 0:0 | ||||
| Group B | 24/11/2010 | FC Schalke 04 | - | Olympique Lyonnais | 3:0 | ||||
| Group B | 07/12/2010 | SL Benfica | - | FC Schalke 04 | 1:2 | ||||
| Round of 16 | 15/02/2011 | Valencia CF | - | FC Schalke 04 | 1:1 | ||||
| Round of 16 | 09/03/2011 | FC Schalke 04 | - | Valencia CF | 3:1 | ||||
| Quarter-finals | 13/04/2011 | FC Schalke 04 | - | Inter | 2:1 | ||||
| Semi-finals | 26/04/2011 | FC Schalke 04 | - | Manchester United | 0:2 |  |
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| Semi-finals | 04/05/2011 | Manchester United | - | FC Schalke 04 | 4:1 |
Germany
