2. Round | 21/08/2021 | FC Gießen | - | 1. FSV Mainz 05 II | 0:1 | ||||
3. Round | 25/08/2021 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 2:1 | ||||
4. Round | 29/08/2021 | SG Sonnenhof Großaspach | - | 1. FSV Mainz 05 II | 1:3 | ||||
5. Round | 03/09/2021 | 1. FSV Mainz 05 II | - | VfB Stuttgart II | 2:4 | ||||
13. Round | 16/10/2021 | 1. FSV Mainz 05 II | - | Hessen Kassel | 1:3 | ||||
14. Round | 23/10/2021 | FC-Astoria Walldorf | - | 1. FSV Mainz 05 II | 0:2 | ||||
16. Round | 30/10/2021 | 1. FSV Mainz 05 II | - | TSV Schott Mainz | 1:0 | ||||
17. Round | 06/11/2021 | FK Pirmasens | - | 1. FSV Mainz 05 II | 1:1 | ||||
18. Round | 13/11/2021 | 1. FSV Mainz 05 II | - | Bahlinger SC | 3:0 | ||||
19. Round | 20/11/2021 | TSG Balingen | - | 1. FSV Mainz 05 II | 0:1 | ||||
31. Round | 02/04/2022 | 1. FSV Mainz 05 II | - | 1899 Hoffenheim II | 3:2 | ||||
32. Round | 06/04/2022 | Hessen Kassel | - | 1. FSV Mainz 05 II | 2:1 |