| 1. Round | 13/08/2021 | SSV Ulm 1846 | - | FSV Frankfurt | 3:3 | ||||
| 2. Round | 20/08/2021 | FSV Frankfurt | - | Rot-Weiß Koblenz | 0:1 | ||||
| 4. Round | 28/08/2021 | FSV Frankfurt | - | Hessen Kassel | 1:0 | ||||
| 6. Round | 10/09/2021 | FSV Frankfurt | - | 1. FSV Mainz 05 II | 1:2 | ||||
| 7. Round | 14/09/2021 | TSV Schott Mainz | - | FSV Frankfurt | 0:1 | ||||
| 8. Round | 18/09/2021 | FSV Frankfurt | - | FK Pirmasens | 2:2 | ||||
| 9. Round | 25/09/2021 | Bahlinger SC | - | FSV Frankfurt | 1:0 | ||||
| 11. Round | 02/10/2021 | VfR Aalen | - | FSV Frankfurt | 1:0 | ||||
| 12. Round | 09/10/2021 | FSV Frankfurt | - | FC Gießen | 2:2 | ||||
| 13. Round | 16/10/2021 | TSV Steinbach Haiger | - | FSV Frankfurt | 3:1 | ||||
| 18. Round | 13/11/2021 | SV 07 Elversberg | - | FSV Frankfurt | 4:2 | ||||
| 19. Round | 21/11/2021 | FSV Frankfurt | - | Kickers Offenbach | 0:2 | ||||
| 20. Round | 27/11/2021 | FSV Frankfurt | - | SSV Ulm 1846 | 0:0 | ||||
| 21. Round | 04/12/2021 | Rot-Weiß Koblenz | - | FSV Frankfurt | 0:0 | ||||
| 22. Round | 11/12/2021 | FSV Frankfurt | - | 1899 Hoffenheim II | 3:0 |  |
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| 23. Round | 18/12/2021 | Hessen Kassel | - | FSV Frankfurt | 0:0 |  |
Germany