1. Round | 15/08/2021 | 1899 Hoffenheim II | - | SG Sonnenhof Großaspach | 1:1 | ||||
2. Round | 21/08/2021 | VfB Stuttgart II | - | 1899 Hoffenheim II | 1:3 | ||||
3. Round | 24/08/2021 | 1899 Hoffenheim II | - | FSV Frankfurt | 3:1 | ||||
4. Round | 28/08/2021 | FC 08 Homburg | - | 1899 Hoffenheim II | 3:3 | ||||
5. Round | 04/09/2021 | 1899 Hoffenheim II | - | SV 07 Elversberg | 1:2 | ||||
6. Round | 10/09/2021 | Kickers Offenbach | - | 1899 Hoffenheim II | 1:0 | ||||
7. Round | 14/09/2021 | 1899 Hoffenheim II | - | SSV Ulm 1846 | 1:2 | ||||
8. Round | 18/09/2021 | Rot-Weiß Koblenz | - | 1899 Hoffenheim II | 0:2 | ||||
12. Round | 08/10/2021 | 1899 Hoffenheim II | - | 1. FSV Mainz 05 II | 0:1 | ||||
13. Round | 16/10/2021 | TSV Schott Mainz | - | 1899 Hoffenheim II | 1:1 | ||||
18. Round | 13/11/2021 | 1899 Hoffenheim II | - | FC Gießen | 1:2 | ||||
19. Round | 20/11/2021 | TSV Steinbach Haiger | - | 1899 Hoffenheim II | 3:3 | ||||
20. Round | 26/11/2021 | SG Sonnenhof Großaspach | - | 1899 Hoffenheim II | 0:0 | ||||
21. Round | 03/12/2021 | 1899 Hoffenheim II | - | VfB Stuttgart II | 2:0 | ||||
22. Round | 11/12/2021 | FSV Frankfurt | - | 1899 Hoffenheim II | 3:0 |