3. Round | 25/08/2021 | Wuppertaler SV | - | Rot-Weiss Essen | 0:1 | ||||
10. Round | 02/10/2021 | Rot-Weiss Essen | - | Rot-Weiß Oberhausen | 1:1 | ||||
11. Round | 09/10/2021 | KFC Uerdingen 05 | - | Rot-Weiss Essen | 0:11 | ||||
12. Round | 16/10/2021 | Rot-Weiss Essen | - | SC Wiedenbrück | 0:0 | ||||
14. Round | 30/10/2021 | Rot-Weiss Essen | - | Alemannia Aachen | 2:1 | ||||
15. Round | 05/11/2021 | Bor. Mönchengladbach II | - | Rot-Weiss Essen | 1:2 | ||||
16. Round | 13/11/2021 | Rot-Weiss Essen | - | Sportfreunde Lotte | 3:1 | ||||
18. Round | 27/11/2021 | Rot-Weiss Essen | - | SV Rödinghausen | 1:0 | ||||
20. Round | 10/12/2021 | Rot-Weiss Essen | - | Bonner SC | 6:1 | ||||
21. Round | 18/12/2021 | SV 19 Straelen | - | Rot-Weiss Essen | 0:1 |