| 2. Round | 20/08/2021 | FSV Frankfurt | - | Rot-Weiß Koblenz | 0:1 | ||||
| 3. Round | 24/08/2021 | Rot-Weiß Koblenz | - | FC 08 Homburg | 4:0 |  |
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| 4. Round | 28/08/2021 | SV 07 Elversberg | - | Rot-Weiß Koblenz | 4:1 | ||||
| 5. Round | 04/09/2021 | Rot-Weiß Koblenz | - | Kickers Offenbach | 1:1 |  |
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| 24. Round | 11/02/2022 | Kickers Offenbach | - | Rot-Weiß Koblenz | 0:1 | ||||
| 25. Round | 19/02/2022 | Rot-Weiß Koblenz | - | SSV Ulm 1846 | 1:1 | ||||
| 27. Round | 06/03/2022 | 1899 Hoffenheim II | - | Rot-Weiß Koblenz | 1:1 | ||||
| 28. Round | 13/03/2022 | Rot-Weiß Koblenz | - | Hessen Kassel | 2:2 | ||||
| 29. Round | 18/03/2022 | FC-Astoria Walldorf | - | Rot-Weiß Koblenz | 2:1 | ||||
| 31. Round | 02/04/2022 | TSV Schott Mainz | - | Rot-Weiß Koblenz | 1:2 | |
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| 32. Round | 05/04/2022 | Rot-Weiß Koblenz | - | FK Pirmasens | 1:2 | ||||
| 33. Round | 09/04/2022 | Bahlinger SC | - | Rot-Weiß Koblenz | 1:0 | ||||
| 34. Round | 16/04/2022 | Rot-Weiß Koblenz | - | TSG Balingen | 0:1 | ||||
| 35. Round | 22/04/2022 | VfR Aalen | - | Rot-Weiß Koblenz | 0:0 | |
Germany