| 16. Round | 30/10/2021 | 1899 Hoffenheim II | - | TSG Balingen | 1:2 | ||||
| 17. Round | 06/11/2021 | VfR Aalen | - | 1899 Hoffenheim II | 5:2 | ||||
| 18. Round | 13/11/2021 | 1899 Hoffenheim II | - | FC Gießen | 1:2 |  |
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| 22. Round | 11/12/2021 | FSV Frankfurt | - | 1899 Hoffenheim II | 3:0 | ||||
| 23. Round | 17/12/2021 | 1899 Hoffenheim II | - | FC 08 Homburg | 2:1 | ||||
| 34. Round | 17/04/2022 | 1899 Hoffenheim II | - | Bahlinger SC | 0:0 |
Germany