| 4. Round | 19/09/2020 | SV Lippstadt 08 | - | 1. FC Köln II | 1:1 |  |
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| 9. Round | 18/10/2020 | 1. FC Köln II | - | Rot-Weiß Oberhausen | 4:0 | ||||
| 10. Round | 21/10/2020 | FC Schalke 04 II | - | 1. FC Köln II | 3:0 | ||||
| 11. Round | 24/10/2020 | 1. FC Köln II | - | SV Rödinghausen | 3:1 | ||||
| 13. Round | 04/11/2020 | 1. FC Köln II | - | SV 19 Straelen | 2:0 |  |
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| 14. Round | 07/11/2020 | VfB Homberg | - | 1. FC Köln II | 3:1 | ||||
| 16. Round | 21/11/2020 | Alemannia Aachen | - | 1. FC Köln II | 0:0 | ||||
| 18. Round | 28/11/2020 | 1. FC Köln II | - | Sportfreunde Lotte | 2:0 | ||||
| 19. Round | 05/12/2020 | Rot-Weiss Essen | - | 1. FC Köln II | 3:1 | |
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| 20. Round | 12/12/2020 | 1. FC Köln II | - | SC Wiedenbrück | 1:1 | ||||
| 23. Round | 23/01/2021 | 1. FC Köln II | - | Borussia Dortmund II | 0:3 | ||||
| 21. Round | 27/01/2021 | 1. FC Köln II | - | Bonner SC | 1:1 | ||||
| 25. Round | 06/02/2021 | 1. FC Köln II | - | SV Lippstadt 08 | 2:1 | ||||
| 26. Round | 10/03/2021 | Fortuna Düsseldorf II | - | 1. FC Köln II | 3:2 | ||||
| 32. Round | 27/03/2021 | SV Rödinghausen | - | 1. FC Köln II | 4:1 | ||||
| 41. Round | 28/05/2021 | SC Wiedenbrück | - | 1. FC Köln II | 1:1 | ||||
| 42. Round | 05/06/2021 | Bonner SC | - | 1. FC Köln II | 1:0 | |
Germany