| 20. Round | 22/01/2022 | Bor. Mönchengladbach | - | 1. FC Union Berlin | 1:2 | ||||
| 26. Round | 12/03/2022 | 1. FC Union Berlin | - | VfB Stuttgart | 1:1 | ||||
| 28. Round | 01/04/2022 | 1. FC Union Berlin | - | 1. FC Köln | 1:0 | ||||
| 29. Round | 09/04/2022 | Hertha BSC | - | 1. FC Union Berlin | 1:4 | ||||
| 30. Round | 17/04/2022 | 1. FC Union Berlin | - | Eintracht Frankfurt | 2:0 | ||||
| 31. Round | 23/04/2022 | RB Leipzig | - | 1. FC Union Berlin | 1:2 |  |
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| 32. Round | 29/04/2022 | 1. FC Union Berlin | - | SpVgg Greuther Fürth | 1:1 |
Denmark