| 1. Round | 14/08/2021 | Rot-Weiß Koblenz | - | VfB Stuttgart II | 0:3 | ||||
| 3. Round | 25/08/2021 | Hessen Kassel | - | VfB Stuttgart II | 3:2 |  |
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| 4. Round | 29/08/2021 | VfB Stuttgart II | - | FC-Astoria Walldorf | 2:3 | ||||
| 7. Round | 15/09/2021 | FK Pirmasens | - | VfB Stuttgart II | 2:3 | |
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| 8. Round | 18/09/2021 | VfB Stuttgart II | - | Bahlinger SC | 0:1 | |
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| 11. Round | 02/10/2021 | FC Gießen | - | VfB Stuttgart II | 2:1 | ||||
| 13. Round | 17/10/2021 | SG Sonnenhof Großaspach | - | VfB Stuttgart II | 1:1 | ||||
| 15. Round | 26/10/2021 | VfB Stuttgart II | - | FSV Frankfurt | 1:1 | ||||
| 16. Round | 31/10/2021 | FC 08 Homburg | - | VfB Stuttgart II | 0:0 | ||||
| 21. Round | 03/12/2021 | 1899 Hoffenheim II | - | VfB Stuttgart II | 2:0 | ||||
| 22. Round | 11/12/2021 | VfB Stuttgart II | - | Hessen Kassel | 1:3 | ||||
| 24. Round | 12/02/2022 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 25. Round | 19/02/2022 | TSV Schott Mainz | - | VfB Stuttgart II | 2:1 |
Germany
Croatia